pMEVHA-KRAS2B-WT

Human K-Ras 2B Xpress Clones Ras proteins are members of small GTPase superfamily. They bind GDP/GTP and possess intrinsic GTPase activity. These proteins act as switches to turn on/off their downstream target proteins in response to upstream stimuli because they can alternate between an inactive form bound to GDP and an active form bound to GTP. Activating mutations of KRAS2, including G12V, have been implicated in various malignancies, including lung denocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. On the other hand, S17N is a widely used dominant negative mutant.Alternative splicing of KRAS-2 gene leads to variants encoding two isoforms that differ in the C-terminal region. KRAS-2B variant terminates in exon 4b, encoding a unique C terminus and lacks exon 4a that is present in the longer transcript variant KRAS-2A.Gene Name: Homo sapiens v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog (KRAS2), transcript variant B. Other Names: Transforming protein p21b, K-Ras 2B, Ki-Ras, c-K-ras - 20 ug