Human P53

Human p53 Xpress Clones express p53, a 53 kDa tumor suppressor protein crucial for regulating the cell cycle in response to genotoxic stress like radiation or chemicals causing DNA damage. The p53 gene is frequently mutated in human cancers, with loss or mutations occurring in over 50% of tumors. p53 modulates key genes such as p21, MDM2, Bax, and cyclin G and plays a critical role in arresting the cell cycle at G1 phase. The native p53 protein forms a tetramer and functions as a transcription factor binding to specific DNA sequences. Mutations in the DNA-binding domain (e.g., V143A), a common hot-spot mutation, result in transdominant-negative effects on wild-type p53. The V143A mutant is also temperature-sensitive, showing activity at 32°C but becoming inactive at 37°C. These clones are valuable for studying p53-related signaling, cancer biology, and genotoxic stress response. - 20 ug each